Identification of the substancemixture and of the companyundertaking. Belviq lorcaserin hydrochloride tablets, for oral use, civ. Lorcaserin diet pills are to be taken before, during or after food intake. Enzyme kinetics assays for lorcaserin nsulfamate formation with cytosol. Lorcaserin hcl tablets buy belviq 10 mg in the usa. Lorcaserin has been approved by the fda for the treatment of obesity with lifestyle modification, but since its introduction in 20 its sales are in decline, probably due to its overall modest. Placement of lorcaserin into schedule iv on december 19, 2012.
Lorcaserin hcl for the treatment of obesity request pdf. Jan 07, 2020 belviq lorcaserin hydrochloride is a serotonin 2c receptor agonist indicated for the treatment of chronic weight management in adults with a body mass index of 30 or greater as an addition to a reducedcalorie diet and exercise. Labchem inc jacksons pointe commerce park building, 1010 jacksons pointe court 16063 zelienople, pa usa t 4128265230 f 7244730647. Of equal concern is the finding that lorcaserin seems to be associated with an increased incidence of depression or 1. Our main products are enzalutamidecas no 915087331, brexpiprazolecas no 9611979,etc. Lorcaserin is used to help adults who are obese or who are overweight and have weightrelated medical problems to lose weight and keep from gaining back that weight. Calcium carbide reacts with hydrogen chloride gas with incandescence. Lorcaserin hydrochloride crm safety data sheet section 2.
Lorcaserin hydrochloride is chemically designated as r8chloro1methyl2,3,4,5tetrahydro1h3benzazepine hydrochloride hemihydrate. Indication for lorcaserin use is obesity or overweight, which is accompanied with some cardiometabolic disorders e. Dailymed belviq xr extended release extended release. In bloomdiabetes mellitus dm, there was also an increase in adverse events related to ischaemic heart. Jul 25, 2016 belviq xr extended release extended release lorcaserin hydrochloride tablet, film coated, extended release if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will be specified as such. Material safety data sheet caustic soda lye csl msds name. Lorcaserin hcl belviq is a drug that promotes weight loss by affecting the brains hypothalamus. Lorcaserin has serotonergic properties and acts as an anorectic. Lorcaserin hydrochloride patents expiry expiration. Lorcaserin hydrochloride powder is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure. Belviq lorcaserin hydrochloride tablets, for oral use, civ initial u. Lorcaserin hcl is a 5hydroxytryptamine 5ht 2c agonist with a chemical formula of r8chloro1methyl2,3,4,5tetrahydro1h3benzazepine hydrochloride hemihydrate. Mar 06, 2020 selective serotonin type 2c 5hydroxytryptamine 5ht 2c receptor agonist.
Lorcaserin hydrochloride safety data sheet section 2. Lorcaserin hcl api manufacturers suppliers drug master. Identification of the substancepreparation and of the. Belviq 10mg is manufactured by arena pharmaceuticals gmbh company. Lorcaserin hcl apd356 hcl is a selective full agonist of human 5ht2c receptor with ki of 15 nm. Lorcaserin is in a class of medications called serotonin receptor agonists. Lorcaserin hydrochloride hemihydrate drug entry lorcaserin. Maximal dose of lorcaserin 20mg should be divided into 2 intakes one lorcaserin 10mg pill in the morning, the other one in the afternoon. Section 5 fire fighting measures general information. Pdf on dec 1, 20, mohammad imran and others published locaserin. Dingmin pharma china lorcaserin hclcas no 846589988.
There is a large variety of weight loss drugs in the usa, many of them are sold by prescription only. Serotonin receptor selectivity profile of lorcaserin background. Lorcaserin is a selective serotonin agonist that is approved as a weight loss agent. Rubidium acetylene carbides burns with slightly warm hydrochloric acid. Indications and usage belviq is a serotonin 2c receptor agonist indicated as an adjunct to a reducedcalorie diet and increased physical activity for chronic weight management in adults with an initial body mass index bmi of. Lorcaserin hydrochloride monograph for professionals. Uranium phosphide reacts with hydrochloric acid to release spontaneously flammable phosphines. Belviq xr belviq lorcaserin hydrochloride extendedrelease tablets for oral use, civ initial u. In 2012, the list of weight loss products available at the u. Buy lorcaserin buy lorcaserin diet pill online where. There are few drugs for treatment of obesity like orlistat and recentlty approved drug lorcaserin.
The fda approved lorcaserin belviq lorcaserin hcl buy belviq. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without a warranty of any kind, expressed or implied. Material safety data sheet of lorcaserin hydrochloride contains identification of substance and details of the supplier of the safety data sheet. Subchronic effects rats administered doses of doxycycline hydrochloride up to 500 mgkgday for 30 days showed. Clean up spills immediately, observing precautions in the protective. Lorcaserin 10mg tablet twice daily was approved in 2012 and a slow release preparation belviq xr, 20 mg once daily was approved in july and launched in october 2016. Belviq belviq xr lorcaserin hydrochloride is a serotonin 2c receptor agonist for oral administration used for chronic weight management. Use proper personal protective equipment as indicated in section 8. The weight loss drug belviq is based on the active component called lorcaserin hydrochloride and is created and distributed by the arena pharmaceuticals. Material safety data sheet of lorcaserin hydrochloride. Articles of lorcaserin hydrochloride hemihydrate are included as well. This material may not be completely removed by conventional laundering.
May cause eye, skin, or respiratory system irritation. Fda approved lorcaserin hcl for the treatment of obesity slideshare. Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Lorcaserin has been in clinical use for a short time only, but has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent liver injury. Lorcaserin belviq is a usapproved weight loss agent. Lorcaserin is one of the last three drugs approved by the fda to treat adult people who are really suffering from excess fat. Under steady state dosing conditions with lorcaserin hcl 20 mg xr, the food effect observed after single dosing was. As in any fire, wear a selfcontained breathing apparatus in pressuredemand, mshaniosh approved or equivalent, and full protective. Safety data sheet according to federal register vol. Dailymed belviq lorcaserin hydrochloride hemihydrate.
It reduces appetite by activating a type of serotonin receptor known as the 5ht 2c receptor in a region of the brain called the hypothalamus, which is known to control appetite. If irritation occurs or persists, get medical attention. It has a role as an appetite depressant and a serotonergic agonist. Belviq also known as lorcaserin hcl is the first obesity drug to be approved by fda in years. Lorcaserin hydrochloride hemihydrate is a hydrate that is the hemihydrate form of lorcaserin hydrochloride. You need to know about lorcaserin hcl powder aasraw. Jul 04, 2014 each belviq tablet contains lorcaserin hydrochloride 10mg lorcaserin equivalent. First aid measures description of first aid measures.
May be harmful by inhalation, ingestion, or skin absorption. Lorcaserin hydrochloride apd356 cas 846589988 abmole. Selective serotonin type 2c 5hydroxytryptamine 5ht 2c receptor agonist. Lorcaserin hcl powder is a very effective weight loss drug and is very popular in the market.
Inactive ingredients include silicified microcrystalline. Lorcaserin hydrochloride hemihydrate c22h32cl4n2o pubchem. Lorcaserin must be used along with a reduced calorie diet and an exercise plan. Lorcaserin hcl safety data sheet hazard description in line with the ghs system of classification, lorcaserin hydrochloride is a category iv. India veritas house, 70 mint road, fort, mumbai 400 001. Lorcaserin previously apd356, a highly selective 5ht2c receptor agonist, is used for the treatment of obesity. Lorcaserin drug is sold in the usa under the trade name belviq. Caustic soda lye csl, 50 wt% solution in water synonyms. Lorcaserin drug can cause insomnia, so it is not recommended for use in the evening. Lithium silicide in contact with hydrogen chloride becomes incandescent.
Pending revision, the material in this section should be considered in light of more recently available information in the medwatch notification at the beginning of this monograph. Federal register schedules of controlled substances. The original nda submission included two sets of studies which addressed the binding affinity and receptor activation kinetics for lorcaserin against the human 5ht2a, 2b, and 2c receptors. Leading supplier of anticancer chemical reagents and kinase. The following information is not intended to endorse any particular medication. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5ht2c receptor may alter body weight by regulating. People taking lorcaserin hcl eat less and feel fuller. Apr 08, 2018 lorcaserin hydrochloride is chemically designated as r8chloro1methyl2,3,4,5tetrahydro1h3benzazepine hydrochloride hemihydrate. Each belviq tablet contains lorcaserin hydrochloride 10mg lorcaserin equivalent. Lorcaserin hydrochloride safety data sheet supersedes revision. Belviq xr lorcaserin hydrochloride extended release tablets.
Contains nonbinding recommendations draft guidance on lorcaserin hydrochloride recommended mar 2015 this draft guidance, once finalized, will represent the food and drug administration s fdas. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5ht2c receptor may alter body weight by regulating satiety. Vacuum or sweep up material and place into a suitable disposal container. Buy 5ht receptor inhibitor lorcaserin hydrochloride apd356 from abmole bioscience.
Caroline day phd, frsb, in practical guide to obesity medicine, 2018. Patents listed in the fda orange book drug database of lorcaserin hydrochloride with information and expiryexpiration dates. This article covers all of the knowledge of lorcaserin hcl powder, which must be read carefully before you buy lorcaserin hcl powder online. Belviq 10mg tablets are round, biconvex, filmcoated. Material safety data sheet potassium chromate 3 section 6 accidental release measures general information.
Belviq lorcaserin hydrochloride tablets, for oral use initial u. Its chemical name is r8chloro1methyl2,3,4,5tetrahydro1h3benzazepine hydrochloride hemihydrate. Lorcaserin hcl hemihydrate is a selective 5ht2c serotonin receptor agonist. Hydrochloric acid, 37% ww safety data sheet according to federal register vol. Obesity is a major comorbidity with hypertension and diabetes mellitus.
Identification of the substancemixture and of the companyundertaking product name. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves. Belviq lorcaserin, together with lowercalorie diet plan and regular exercise, can help achieve incredible results in terms of weight loss and health. Belviq is a serotonin 2c receptor agonist indicated as an adjunct to a reducedcalorie diet and increased physical activity for chronic weight. Lorcaserin, marketed under the brand name belviq is a weightloss drug developed by arena pharmaceuticals. However, we make no warranty of merchantability or any other warranty, express or implied, with. Identification of human sulfotransferases involved in. Lorcaserin hcl powder works by helping you feel full with smaller meals. Fda briefing document nda 22529 lorcaserin hydrochloride. Lorcaserin, currently marketed under the trade name belviq and previously lorqess during development, is a weightloss drug developed by arena pharmaceuticals. Find patient medical information for lorcaserin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Lorcaserin hydrochloride 99 by hplc manufacturers and suppliers around the world who offer high quality lorcaserin hydrochloride 99 by hplc on.
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